Disodium trans-crocetinate (TSC) is an innovative bipolar trans-carotenoid salt that acts as a potent oxygen diffusion enhancer by increasing the rate of oxygen movement through blood plasma into hypoxic tissues. It serves as a high-affinity NMDA receptor antagonist and an exceptional antioxidant, demonstrating significant efficacy in mitigating cerebral ischemia-reperfusion injury, treating hemorrhagic shock, and protecting the central nervous system. Additionally, TSC is widely investigated as a radiation and chemotherapy sensitizer for solid tumors, making it a critical active ingredient and intermediate for advanced pharmaceutical R&D and life science applications.