规格 / Specification

应用 / Applications

BOC-D-焦谷氨酸乙酯是一种重要的有机化合物中间体及关键手性中间体，用于合成蛋白酶抑制剂和肾素抑制剂等药物活性分子、用于多肽合成中的氨基保护，在肽类或多步合成反应中提高反应效率和产物纯度。该特性使其在精细化学品及生物活性分子合成中具有重要价值。BOC-D-焦谷氨酸乙酯广泛应用于医药、有机合成和生物化学领域。

Ethyl Boc-D-Pyroglutamate is a crucial organic compound intermediate and a key chiral intermediate employed in the synthesis of pharmaceutically active molecules such as protease inhibitors and renin inhibitors, as well as for amino group protection in peptide synthesis, thereby enhancing reaction efficiency and product purity in peptide or multi-step synthetic reactions. This characteristic renders it invaluable in the synthesis of fine chemicals and bioactive molecules. Ethyl Boc-D-Pyroglutamate finds widespread application in the pharmaceutical, organic synthesis, and biochemistry fields.

1. Pharmaceutical Intermediate: Ethyl Boc-D-Pyroglutamate serves as an intermediate in the pharmaceutical industry for the synthesis of drugs, particularly in the creation of compounds with specific biological activities. It is also a significant intermediate in peptide synthesis, used to protect the amino group of amino acids, preventing undesired chemical reactions.

1-1: Synthesis of Peptide Drugs: As a chiral building block, it is utilized in the synthesis of active pharmaceutical ingredients (APIs) containing the pyroglutamic acid structure, such as antitumor drugs, antiviral drugs, and neuropeptide analogs.

1-2: Application of Boc Protecting Group: The tert-butyloxycarbonyl (Boc) group protects amino groups, preventing side reactions and improving product purity in solid-phase peptide synthesis (SPPS).

2. Organic Synthesis: Beyond its applications in peptide and drug synthesis, Ethyl Boc-D-Pyroglutamate can also function as a versatile starting material in general organic synthesis for the creation of various organic compounds.

2-1: Asymmetric Synthesis: As a D-configured pyroglutamic acid derivative, it is used to construct chiral heterocyclic compounds (such as pyrrolidinones), acting as a ligand or substrate in catalytic reactions.

2-2: Transesterification Reactions: The ethyl ester group can be converted into other functional groups (such as carboxylic acids, amides) via hydrolysis or aminolysis, expanding its synthetic applications.

3. Biochemical Research: In biochemical research, Ethyl Boc-D-Pyroglutamate can be employed to synthesize diverse bioactive molecules, aiding researchers in understanding the function and structure of proteins, enzymes, and other biomolecules.

3-1: Enzyme Inhibitor Development: By mimicking the natural pyroglutamic acid structure, it is used to design protease or kinase inhibitors, facilitating the study of enzyme mechanisms of action.

3-2: Fluorescent Labeling Precursor: Upon modification, it can be conjugated with fluorescent groups for biomolecule labeling or probe synthesis.

4. Other Applications:

4-1: Synthesis of Ionic Liquids: As a quaternary ammonium salt precursor, it participates in the preparation of functionalized ionic liquids.

4-2: Materials Science: It is used as a chiral unit in the synthesis of polymeric materials or liquid crystal compounds.

4-3: Moisturizing and Skin Conditioning Agent: Although primarily used in biochemical and pharmaceutical fields, its derivatives or related compounds may possess moisturizing and skin-conditioning properties, potentially finding applications in skincare products.

包装 / Packing

1/10/25kgs/drum

运输编号 / UN number

普通化学品 / Not dangerous goods

储存条件 / Store at

密封保存于阴凉干燥处，避光避热 / Sealed storage in a cool and dry place, avoid light and heat.

保质期 / Shelf Life

两年 / Two years